Hyper Eosinophillic Syndrome

DESCRIPTION – this syndrome occurs due to the high number of eosinophils

COMPONENT – FGFR1

CLINICAL UTILITY – FGFR1 rearrangement, PDGFRA/FIP1LIA fusion, PDGFRB rearrangement, CBFB/INV by FISH

METHODOLOGY – fluorescence in situ hybridization (FISH)

TURN AROUND TIME – 12 days

PATIENT PREPARATION –

COLLECT – non diluted bone marrow aspirate or sodium heparin

SPECIMEN PREPARATION – 3-4 ml bone marrow or peripheral blood in green top or lavender top tube

STORAGE/TRANSPORT TEMPERATURE – 2-8 degrees C (with cold pack) and transport within 72 hours

STABILITY – ambient: 48 hours; refrigerated: 48 hours

UNACCEPTABLE CONDITIONS – clotted specimens

MRP – 16000.00

SPECIAL INSTRUCTIONS – clinical history is mandatory