Double/Triple hit lymphoma (blood and BM)

COMPONENTS – Bcl2, Bcl6, c-MYC

CLINICAL UTILITY – diagnosis and therapeutic indication in cases of lymphoma, c-MYC gene rearrangement and Bcl6 gene rearrangement

METHODOLOGY – fluorescence in situ hybridization (FISH)

TURN AROUND TIME – 12 days

PATIENT PREPARATION –

COLLECT – tumor tissue

SPECIMEN PREPARATION – formalin fixed paraffin embedded tissue block. Protect the slides from excessive heat

STORAGE/TRANSPORT TEMPERATURE – room temperature (18-25 degrees C)

STABILITY – ambient: indefinitely; refrigerated: indefinitely

UNACCEPTABLE CONDITIONS – alternate fixatives and decalcified specimen

MRP – 15000

SPECIAL INSTRUCTIONS – clinical history is mandatory including surgical pathology reports